Good solution for low volume book binding. Perfect Binding or also known as Hot Melt Binding is a low cost and inexpensive for runs of 1,000-5,000. can bind single sheets with a grith up to 2 3/8".
Signatures are gathered in a stack, the spine side of the stack is milled to remove the folded edges. Melted adhesive is applied along the spine edges of the pages. The cover is applied while the glue is hot and wrappped around the book.